Prostatitis Research? benign prostatic hyperplasia, diagnosis and medical treatment

Dr. Ronald Wheeler invented an herbal preparation called Peenuts® for prostate cancer, and has sent us this abstract with statistically significant data, which we are happy to post here with his permission. Since the rise and fall of PC SPES for prostate cancer I have taken an increased interest in herbal medications. Remember we do not endorse any one treatment or physician but provide information here. – Bradley Hennenfent, MD

Statistical Analysis
Comparison of PSA Levels:
Before and After Treatment with Peenuts®

The following study was conducted at The Prostate Center, Sarasota, Florida by Dr. Ronald Evan Wheeler. The purpose of the study was to test for a significant difference in the PSA (Prostate Specific Antigen) levels of twenty prostate cancer patients treated with the herbal formula Peenuts®. The age range of the patients was 43 years old to 72 years old. These patients were studied over a variable period from 5 months to 64 months. The study took place from April 1999 to September 2004.

	Data: Patient			Age	PSA at Diagnosis (ng/ml)	Months	PSA at Follow-Up (ng/ml)
		1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 ___________ Totals Mean		61 68 43 65 64 55 56 70 68 56 61 48 69 56 74 63 71 64 70 72 1254 62.7	8.5 7 4.7 11.7 2.9 2.1 7.3 6.9 5.8 9.1 3 3.2 6.2 4.4 11.4 6.8 6.6 14.4 8.4 4.4 134.8 6.74	64 60 30 38 60 34 33 19 31 47 24 13 10 24 28 33 12 14 5 11 590 29.5	2.9 2.8 2.1 7.6 1.5 3.0 4.2 5.1 4.9 4.9 0.8 2.2 3.2 1.9 10.9 1.9 4.7 1.9 3.0 5.0 74.5 3.73

ng/ml = nanograms per milliliter

Descriptive Statistics:

______________________________
PSA at Diagnosis Ø
______ ___ _ 0______

______________________________

______PSA at Diagnosis Ø________

Mean
Standard Error
Median
Mode
Standard Deviation
Sample Variance
Kurtosis
Skewness
Range
Minimum
Maximum
Sum
Count

6.74
0.718052923
6.7
4.4
3.211230294
10.312
0.319273095
0.720065776
12.3
2.1
14.4
134.8
20

Mean
Standard Error
Median
Mode
Standard Deviation
Sample Variance
Kurtosis
Skewness
Range
Minimum
Maximum
Sum
Count

3.725
0.526351644
3
1.9
2.35391611
5.540921053
3.59465374
1.668528589
10.1
0.8
10.9
74.5
20

The null hypothesis: H0 that Ø = Ø
0
The alternative hypothesis: H1 that Ø < Ø
0
Level of significance: a = 0.05
Test statistic: T test

t-Test: Two-Sample Assuming Unequal Variances

___________________________________________________________________
	PSA at Diagnosis	PSA at Follow-up
___________________________________________________________________
Mean Variance Observations Hypothesized Mean Difference df t Stat P(T< t) one-tail t Critical one-tail P(T< t) two-tail t Critical two-tail	6.74 10.312 20 0 35 3.386473378 0.000880968 1.689572855 0.001761936 2.030110409	3.725 5.540921053 20
___________________________________________________________________

SUMMARY

     Statistical evaluation for the change in Prostate Specific Antigen, PSA levels was significant using the t-Test. The decision is to reject the null hypothesis that there was no change in PSA levels. There was a significant decrease in the PSA levels (ng/ml) of the patients after treatment with the herbal formula Peenuts®. The P value for P(T= t) one-tailed T test is 0.000880968. The dosage of the herbal formula Peenuts was two capsules daily.
      There are twenty subjects in the study. Two subjects, Patient Number 6 and Patient Number 20 had slight increases in their PSA levels. The other eighteen patients all had decreased PSA levels. Therefore 90% of the patients treated with the formula had decreased PSA levels.
      Patient Number 18 had the largest decrease from PSA 14.4 ng/ml at diagnosis to PSA 1.9 ng/ml at follow-up after 14 months. Considering this subject to be an outlier, we re-evaluated the data using 19 patients. The results are as follows:

t-Test: Two-Sample Assuming Unequal Variances

___________________________________________________________________
	PSA at Diagnosis	PSA at Follow-up
___________________________________________________________________
Mean Variance Observations Hypothesized Mean Difference df t Stat P(T< t) one-tail t Critical one-tail P(T< t) two-tail t Critical two-tail	6.33684211 7.45356725 19 0 35 3.02893837 0.00229453 1.68957285 0.00458906 2.03011041	3.821053 5.653977 19
___________________________________________________________________

At the significance level of alpha = 0.05: the P one-tailed test (T= t) is 0.00229453. Thus, there is a significant decrease in the PSA level with these 19 subjects.
Statistical evaluation of the herbal formula Peenuts® has a significant effect in reducing PSA levels in this subject group. Prostate Specific Antigen is a common measure in the prediction of Prostate Cancer. The herbal formula Peenuts® can help to lower PSA levels in most subjects. Treatment with the standard dosage of two capsules of Peenuts® daily may also be used as preventive nutrient in an effort to alter the natural history of Prostate Cancer in future studies.

Microsoft Excel Data Analysis Tools were used in the statistical calculations.

Message Board

To learn more about Prostatitis Research

Today is : November 20, 2008
You are visitor number:
Disclaimer